Uruguay comfortably saw off World Cup hosts Russia 3-0 in Samara on Monday to seal top spot in Group A.
Oscar Tabarez's side made light work of the hosts, winning thanks to a Luis Suarez free kick, a Denis Cheryshev own goal and a late Edinson Cavani strike.
Russia, who had already qualified for the last 16 after wins over Saudi Arabia and Egypt, were also reduced to 10 men before the break, full-back Igor Smolnikov sent off for two yellow cards after 36 minutes.
Suarez opened the scoring in the 10th minute with his seventh World Cup goal.